When prophylactic CLND is performed, many CLN metastases are microscopic deposits. Recently, PTC has been diagnosed at earlier stages through screening. Thus, identification of predictive factors for CLN metastasis might prevent unnecessary contralateral CLND. However, CLND might increase the rates of hypoparathyroidism and vocal cord palsy, especially when bilateral CLND is performed. Prophylactic central lymph node dissection (CLND) is an accepted procedure for patients with PTC. However, this conventional knowledge has become debated due to a large, recent case-based study which showed an increased mortality rate in patients with regional lymph node metastasis. CLN metastasis is a well-known independent risk factor in local recurrence but has little adverse effect on survival. The occurrence of CLN metastasis ranges from 40% to 90% of PTC cases. Although PTC has a good prognosis, central lymph node (CLN) metastases are common. Papillary thyroid carcinoma (PTC) makes up 85% to 90% of all thyroid carcinoma cases, with a reported 10-year survival rate of more than 90%. Thyroid carcinoma accounts for approximately 1% of all tumors and one third of all head and neck tumors.
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